 |
 |
 |
 |
 |
 |
|
|
|
|
|
09/07/2010
New Vinco Products Now In Stock We are proud to officially announce eight new supplements to the Vinco line. We have these in house and are ready to ship them out. Please read on for more information on these new supplements.
 Full Story
|
|
|
05/04/2010
What Makes Vinco’s OsteoSheath so Great? Key factors to a healthy bone structure include a balanced diet, weight-bearing exercise, reduction and/or elimination of smoking and alcohol, and a quality source of calcium.
Full Story
|
|
|
|
 |
|
|
|
Please enter your full email address above.
Our newsletters feature the latest news and product updates for all Vinco products.
Sign up today!
! |
|
|
|
 |
 |
 |
 |
|
|
|
Phosphatidyl Serine
|
|
Item # VP-PTS
60 Vegetarian Capsules per bottle
Enhancing Cerebral Metabolism
• Provides nutritional support for brain functions.
• Essential for healthy brain cells.
• Benefits cognition, memory recall, nerve transmission, and function.
Vinco's Phosphatidyl Serine
The ingredients in Vinco's Phosphatidyl Serine have been shown to be beneficial in providing nutritional support for brain functions.Phosphatidyl Serine is essential for healthy brain cells, and has been shown to benefit cognition, memory recall, nerve transmission, and function.
Overview
Phosphatidylserine (PS) is a phospholipid that is an essential building block of brain cell structure and function. Phospholipids, found in every cell membrane in our bodies, are molecules with an amino acid component and a fatty acid component.PS supports the functions of several membrane proteins, and plays an important role in our neurotransmitter systems, metabolism levels of the brain, and maintaining nerve connections in the brain. It also serves as a reservoir of raw material for the manufacture of eicosanoid (prostaglandin) molecules, which carry hormonal messages to nearby cells.
Functions In The Body
Cell membrane signaling - recent studies indicate that phosphatidylserine plays an integral role in cell membrane signaling, which involves oxidation processes that lead to apoptosis.(2, 3)
Cellular membranes - Phosphatidylserine is an essential component of cellular membranes.(4) It apparently helps influence and regulate the level of fluidity in nerve cell membranes, especially in brain cells.
Clinical Applications
Age-associated memory impairment - elderly individuals experiencing age-associated cognitive decline have been treated with phosphatidylserine (100 mg 3 times daily) for periods ranging from 3 to 6 months.In general, patients exhibit improvements in memory and learning and on measurements of behavior.(5, 6) At the beginning of one study, the subject's averagescores on a name-face acquisition skill tests was the level normally obtained by 64-year old individuals. After 12 weeks of treatment with phosphatidylserine, these same subjects scored at the level of 52-year olds, indicating a 12 year improvement in cognitive biological age functioning.(7)
Alzheimer's Disease - Several studies report that administration of phosphatidylserine to patients with Alzheimer's disease results in measurable cognitiveimprovement in some patients. Frequently, patients with less severe cognitive impairment respond better, which suggests that patients with more advanced disease have a level of neuronal deterioration which cannot be helped by this type of therapy.(8, 9, 10) The dosages used in these was 100 mg given three times daily.
Depression - Elderly people with depressive disorders have benefited from therapy with phosphatidylserine.In addition to the antidepressant activity, patients also make gains in measurements of memory and behavior.(11)
Directions for Use
As a dietary supplement for adults and children 12 or more years of age, take one capsule two times daily, or as directed by a qualified healthcare professional.
These statements have not been evaluated by the FDA.This product is not intended to diagnose, treat, cure or prevent any disease.
References
1 Bruni A, Orlando P, Mietto L, Viola G.Phospholipid metabolism in rat intestinal mucosa after oral administration of lysophospholipids. Adv Exp Med Biol.1992;318:243-9.
2 Tyurina YY, Shvedova AA, Kawai K, et al. Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine.Toxicology.Aug2000;148(2-3):93-101.
3 Kagan VE, Fabisiak JP, Shvedova AA, et al.Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis.FEBS Lett.Jul2000;477(1-2):1-7.
4 Araki W, Wurtman RJ. How is membrane phospholipid biosynthesis controlled in neural tissues? J Neurosci Res. Mar1998;51(6): 667-74.
5 Schreiber S, Kampf-Sherf O, Gorfine M, et al.An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline.Isr J Psychiatry Relat Sci.2000;37(4):302-7.
6 Cenacchi T, Bertoldin T, Farina C, et al.Cognitive decline in the elderly:a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration.Aging.Milano.Apr1993;5(2):123-33.
7 Crook TH, Tinklenberg J, Yesavage J, et al. Effects of phosphatidylserine in age-associated memory impairment. Neurology. May1991;41(5):644-9.
8 Heiss WD, Kessler J, Mielke R, et al.Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease.
A neuropsychological, EEG, and PET investigation.Dementia.Mar1994;5(2):88-98.
9 Engel RR, Satzger W, Gunther W, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type.Eur Neuropsychopharmacol.Jun1992;2(2):149-55.
10 Crook T, Petrie W, Wells C, et al.Effects of phosphatidylserine in Alzheimer's disease.Psychopharmacol Bull.1992;28(1):61-6.
11 Maggioni M, Picotti GB, Bondiolotti GP, et al.Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand.Mar1990;81(3):265-70.
FDA Confirms Phosphatidylserine's Health Claims
FDA reexamined the science.The evidence points to a "risk reduction relationship" between PS and cognitive dysfunction. In May 2003, phospahtidylserine (PS) received some welcome news from the Food and Drug Administration (FDA; Rockville, MD).For the first time, products could be labeled with quality health claims: "Consumption of phosphatidylserine may reduce the risk of dementia in the elderly, "or "Consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly."
While the FDA approved the claim, the agency expressed concern that the science behind PS provided only "very limited and preliminary"evidence that it reduced the risk of dementia or cognitive dysfunction.
After the decision, Jonathan Emord, counsel for petitioner Kyl Smith, wrote FDA to clarify a point about the use of disease treatment studies as evidence of risk reduction. FDA reevaluated the evidence, and in November 2004, it delivered good news for a second time.FDA said that while the evidence was still limited and preliminary and another evaluation might be needed, it found no reason to change the qualified claims.
Remarkably, FDA went so far as to admit that it had made a mistake in its original evaluation.In its May 2003 announcement, FDA said the phosphatidylserine claims were substantiated only with studies involving diseased populations. In fact, four of the studies involved patients with diagnosed dementia or cognitive dysfunction.
The correction was significant."Because there are studies conducted in nondiseased populations demonstrating beneficial effects of phosphatidylserine on subjects at risk of dementia and cognitive dysfunction, "FDA concluded, "there is some credible evidence for a risk reduction relationship."
Why PS?
Reaffirming the science behind the claims opens the door for PS.James Gormley, coauthor of Health Benefits of Phosphatidylserine, describes PS as a critical component of individual health and a way to offset the cognitive decline that benefits after middle age.
To Gormley, it makes sense that PS is important for brain health.PS is a phospholipid that is heavily concentrated in the brain cell membranes that provide structural support and keep cells fluid and flexible.
PS is found in the body, but supplemental PS may have several beneficial effects, according to Gormley. PS may help restore normal levels of the brain neurotransmitter acetylcholine. PS also may inhibit degeneration of dendrites, the parts of the nerve cells that carry impulses to cell bodies.
PS studies generally show that the best results occur in patients with mild cognitive dysfunction. A meta-analysis published in the November/December 2003 issue of Nutrition failed to find a single study that demonstrated positive results in older adults with probable Alzheimer's disease.However, studies consistently showed that PS produced modest increases of recall of word lists among older patients with moderate cognitive impairment.One report found consistent benefits across a number of memory tests for a subset of normal adults who have preformed more poorly that their peers.
The most effective dose is subject for debate.Many supplements contain 100 mg.Gormley suggests 200 mg daily. A landmark study of 48 young, healthy, male university students in the UK reported results with 300 mg per day. Gormley suggests since PS is found naturally in the body, supplemental PS shouldn't pose a problem, and that 300 mg might be a good starting point before lowering the dosage to 100 mg for maintenance.Gormley advises checking with a healthcare practitioner, particularly when taking prescription medications.
June 2005, Nutritional Outlook
|
|
|
|
